Car T Cell Therapy Lymphoma Side Effects

Low white blood.

Car t cell therapy lymphoma side effects.

To prepare the body for car t cell therapy patients receive a small dose of chemotherapy which may cause other side effects such as fatigue and low blood count. As the car t cells work to fight cancer they cause the release of large amounts of other t cells into the blood along with cytokines which are proteins released by cells that communicate to other cells that there s a job to be done. Car t cell therapy involves extracting a cancer patient s white blood cells and reprogramming the t cells the roving warriors of the immune system with an antibody like protein called chimeric antigen receptor or car. The most common side effects seen are.

Serious side effects of this release can include very high fevers and dangerously low blood pressure in the days after treatment is given. The resulting onslaught can produce dangerously high fevers extreme fatigue difficulty breathing and a sharp drop in blood pressure. Some side effects can be severe or fatal. As car t cells multiply they cause massive amounts of chemicals called cytokines to be released into the blood.

The modified cells are returned to the patient s body a process that takes less than 10 minutes. Cytokine release syndrome which is similar to flu like symptoms headache. Car t cell therapy side effects. Cytokine release syndrome crs you may have heard of the cytokine storm in 2018 when many people got seriously ill during flu season.

Once they enter the body car t cells initiate a massive release of proteins called cytokines which summon other elements of the immune system to join the attack on tumor cells. Neurologic events include encephalopathy. Neurologic events can also be experienced and can be serious in some patients. Some people have had serious side effects from this treatment especially as the car t cells multiply in the body to fight the cancer.

Cytokine release syndrome fever and chills low blood pressure and low oxygen levels nervous system problems which might include brain problems encephalopathy headache twitching or shaking tremor. The possible side effects that your doctor will discuss with you include.